Rabbit Polyclonal Antibody to MAP2K2
货号:
P04091
别名:
MEK2, MKK2, MAPKK2, PRKMK2
应用:
WB,IHC
反应种属:
Human, Mouse, Rat
抗体类型:
Primary antibody
Swissprot:
P36507
规格:
目录价
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Description |
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The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. |
Specification |
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Aliases | MEK2, MKK2, MAPKK2, PRKMK2 |
Swissprot | P36507 |
WB Predicted band size | 44 kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human, Mouse, Rat |
Immunogen | Synthetic peptide of human MAP2K2 |
Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
Application |
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WB | 1/1000-1/5000 |
IHC | 1/100-1/300 |
ELISA | 1/2000-1/10000 |
Product Image
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Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Hela cells, NIH/3T3 cells, Jurkat cells, Primary antibody: P04091(MAP2K2 Antibody) at dilution 1/1900, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds
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The image is immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using P04091(MAP2K2 Antibody) at dilution 1/100. (Original magnification: ×200)
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The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P04091(MAP2K2 Antibody) at dilution 1/100. (Original magnification: ×200)