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Rabbit Polyclonal Antibody to MAP2K2
货号: P04091
别名: MEK2, MKK2, MAPKK2, PRKMK2
应用: WB,IHC
反应种属: Human, Mouse, Rat
抗体类型: Primary antibody
Swissprot: P36507
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Description

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.

Specification

Aliases MEK2, MKK2, MAPKK2, PRKMK2
Swissprot P36507
WB Predicted band size 44 kDa
Host/Isotype Rabbit IgG
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human, Mouse, Rat
Immunogen Synthetic peptide of human MAP2K2
Formulation Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.

Application

WB 1/1000-1/5000
IHC 1/100-1/300
ELISA 1/2000-1/10000
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