Rabbit Polyclonal Antibody to RAD50
货号:
P04189
别名:
NBSLD; RAD502; hRad50
应用:
WB,IHC
反应种属:
Human, Mouse, Rat
抗体类型:
Primary antibody
Swissprot:
Q92878
规格:
目录价
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Description |
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The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder. |
Specification |
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Aliases | NBSLD; RAD502; hRad50 |
Swissprot | Q92878 |
WB Predicted band size | 154 kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human, Mouse, Rat |
Immunogen | Synthetic peptide of human RAD50 |
Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
Application |
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WB | 1/500-1/2000 |
IHC | 1/50-1/200 |
ELISA | 1/2000-1/10000 |
Product Image
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Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-5: 293T cells, Hela cells, K562 cells, NIH/3T3 cells, RAW264.7 cells, Primary antibody: P04189(RAD50 Antibody) at dilution 1/900, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes
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The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P04189(RAD50 Antibody) at dilution 1/40. (Original magnification: ×200)
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The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P04189(RAD50 Antibody) at dilution 1/40. (Original magnification: ×200)