Mouse Monoclonal Antibody to PAK2
货号：
20356
别名：
PAK65; PAKgamma
应用：
WB,IHC,IF
反应种属：
Human,Monkey
抗体类型：
Primary antibody
Swissprot：
Q13177
规格：
目录价
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Description |
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PAK2, also known as P21 (CDKN1A)-activated kinase 2. The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. PAK2 is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. PAK2 has been shown to interact with SH3KBP1, CDC42 and Abl gene. |
References |
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| 1. J Immunol. 2004 Jun 15;172(12):7324-34. 2. J Mol Biol. 2007 Jul 20;370(4):620-32. |
Specification |
|
|---|---|
| Aliases | PAK65; PAKgamma |
| Entrez GeneID | 5062 |
| Swissprot | Q13177 |
| clone | 3B5 |
| WB Predicted band size | 61kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Monkey |
| Immunogen | Purified recombinant fragment of PAK2 expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500 - 1/2000 |
| IHC | 1/200 - 1/1000 |
| IF | 1/200 - 1/1000 |
| ELISA | 1/10000 |
Product Image
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Western blot analysis using PAK2 mouse mAb against Hela (1), Jurkat (2), A549 (3), HEK293 (4) and K562 (5) cell lysate.
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Confocal Immunofluorescence analysis of Hela cells using PAK2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.
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Immunohistochemical analysis of paraffin-embedded human lung cancer (left) and gastric cancer (right) using PAK2 mouse mAb with DAB staining.
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