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Rabbit Polyclonal Antibody to GRIN2B
货号: P04149
别名: NR3; MRD6; NR2B; hNR3; DEE27; EIEE27; GluN2B; NMDAR2B
应用: WB,IHC
反应种属: Human, Mouse, Rat
抗体类型: Primary antibody
Swissprot: Q13224
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Description

This gene encodes a member of the N-methyl-D-aspartate (NMDA) receptor family within the ionotropic glutamate receptor superfamily. The encoded protein is a subunit of the NMDA receptor ion channel which acts as an agonist binding site for glutamate. The NMDA receptors mediate a slow calcium-permeable component of excitatory synaptic transmission in the central nervous system. The NMDA receptors are heterotetramers of seven genetically encoded, differentially expressed subunits including NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The early expression of this gene in development suggests a role in brain development, circuit formation, synaptic plasticity, and cellular migration and differentiation. Naturally occurring mutations within this gene are associated with neurodevelopmental disorders including autism spectrum disorder, attention deficit hyperactivity disorder, epilepsy, and schizophrenia.

Specification

Aliases NR3; MRD6; NR2B; hNR3; DEE27; EIEE27; GluN2B; NMDAR2B
Swissprot Q13224
WB Predicted band size 166 kDa
Host/Isotype Rabbit IgG
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human, Mouse, Rat
Immunogen Synthetic peptide of human GRIN2B
Formulation Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.

Application

WB 1/1000-1/5000
IHC 1/50-1/200
ELISA 1/5000-1/10000
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