Rabbit Polyclonal Antibody to SMAD7
货号:
P04203
别名:
CRCS3; MADH7; MADH8
应用:
WB,IHC
反应种属:
Human, Mouse, Rat
抗体类型:
Primary antibody
Swissprot:
O15105
规格:
目录价
在线咨询
Description |
---|
The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. |
Specification |
|
---|---|
Aliases | CRCS3; MADH7; MADH8 |
Swissprot | O15105 |
WB Predicted band size | 46 kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human, Mouse, Rat |
Immunogen | Synthetic peptide of human SMAD7 |
Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
Application |
|
---|---|
WB | 1/500-1/2000 |
IHC | 1/50-1/200 |
ELISA | 1/5000-1/10000 |
Product Image
-
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: LO2 cell lysate, Primary antibody: P04203(SMAD7 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute
-
The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P04203(SMAD7 Antibody) at dilution 1/50. (Original magnification: ×200)