Mouse Monoclonal Antibody to Proteinase 3
货号：
20373
别名：
PRTN3; ACPA; CANCA
应用：
FCM
反应种属：
Human,Mouse
抗体类型：
Primary antibody
Swissprot：
P24158
规格：
目录价
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Description |
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Proteinase 3, also known as PRTN3. PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown but in human neutrophils proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the cANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease Wegener's granulomatosis. |
References |
|---|
| 1. Blood. 2007 Dec 1;110(12):4086-95. 2. Clin Exp Immunol. 2006 Jul;145(1):63-70. |
Specification |
|
|---|---|
| Aliases | PRTN3; ACPA; CANCA |
| Entrez GeneID | 5657 |
| Swissprot | P24158 |
| clone | 3B4 |
| WB Predicted band size | 28kDa |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Purified recombinant fragment of human Proteinase 3 expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| IF | 1/50-1/200 |
| FCM | 1/200 - 1/400 |
| ELISA | 1/10000 |
Product Image
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Flow cytometric analysis of hela cells usingProteinase 3 mouse mAb (green) and negative control (red).
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Flow cytometric analysis of jurkat cells usingProteinase 3 mouse mAb (green) and negative control (red).
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Flow cytometric analysis of NIH3T3 cells usingProteinase 3 mouse mAb (green) and negative control (red).
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