Rabbit Polyclonal Antibody to MOB1B
货号:
P04306
别名:
MATS2; MOB4A; MOBKL1A
应用:
WB
反应种属:
Human, Mouse
抗体类型:
Primary antibody
Swissprot:
Q7L9L4
规格:
目录价
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Description |
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The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been found for this gene. Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. |
Specification |
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Aliases | MATS2; MOB4A; MOBKL1A |
Swissprot | Q7L9L4 |
WB Predicted band size | 25 kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human, Mouse |
Immunogen | Synthetic peptide of human MOB1B |
Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
Application |
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WB | 1/200-1/1000 |
ELISA | 1/1000-1/2000 |