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Rabbit Polyclonal Antibody to NOTCH4
货号: P04393
别名: INT3
应用: WB,IHC
反应种属: Human
抗体类型: Primary antibody
Swissprot: Q99466
规格:
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Description

This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor may play a role in vascular, renal and hepatic development. Mutations in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

Specification

Aliases INT3
Swissprot Q99466
WB Predicted band size 210 kDa
Host/Isotype Rabbit IgG
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Synthetic peptide of human NOTCH4
Formulation Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.

Application

WB 1/800-1/2000
IHC 1/50-1/100
ELISA 1/5000-1/10000
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