Rabbit Polyclonal Antibody to FZD6
货号:
P04518
别名:
FZ6; FZ-6; HFZ6; NDNC10
应用:
IHC
反应种属:
Human, Mouse
抗体类型:
Primary antibody
Swissprot:
O60353
规格:
目录价
在线咨询
Description |
---|
This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide. |
Specification |
|
---|---|
Aliases | FZ6; FZ-6; HFZ6; NDNC10 |
Swissprot | O60353 |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human, Mouse |
Immunogen | Synthetic peptide of human FZD6 |
Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
Application |
|
---|---|
IHC | 1/100-1/300 |
ELISA | 1/2000-1/10000 |
Product Image
-
The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P04518(FZD6 Antibody) at dilution 1/60. (Original magnification: ×200)
-
The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P04518(FZD6 Antibody) at dilution 1/60. (Original magnification: ×200)