Rabbit Polyclonal Antibody to FZD6
货号:
P04518
别名:
FZ6; FZ-6; HFZ6; NDNC10
应用:
IHC
反应种属:
Human, Mouse
抗体类型:
Primary antibody
Swissprot:
O60353
规格:
目录价
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Description |
|---|
This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide. |
Specification |
|
|---|---|
| Aliases | FZ6; FZ-6; HFZ6; NDNC10 |
| Swissprot | O60353 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human FZD6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
Application |
|
|---|---|
| IHC | 1/100-1/300 |
| ELISA | 1/2000-1/10000 |
Product Image
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The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P04518(FZD6 Antibody) at dilution 1/60. (Original magnification: ×200)

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The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P04518(FZD6 Antibody) at dilution 1/60. (Original magnification: ×200)



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