Rabbit Polyclonal Antibody to UPF1
货号:
P04601
别名:
HUPF1; NORF1; RENT1; smg-2; pNORF1
应用:
WB,IHC
反应种属:
Human, Mouse
抗体类型:
Primary antibody
Swissprot:
Q92900
规格:
目录价
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Description |
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This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. Alternative splicing results in multiple transcript variants. |
Specification |
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Aliases | HUPF1; NORF1; RENT1; smg-2; pNORF1 |
Swissprot | Q92900 |
WB Predicted band size | 124 kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human, Mouse |
Immunogen | Synthetic peptide of human UPF1 |
Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
Application |
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WB | 1/200-1/1000 |
IHC | 1/50-1/200 |
ELISA | 1/1000-1/5000 |
Product Image
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Gel: 6%SDS-PAGE, Lysate: 60 μg, Lane: Raji cells, Primary antibody: P04601(UPF1 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes
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The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P04601(UPF1 Antibody) at dilution 1/35. (Original magnification: ×200)
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The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P04601(UPF1 Antibody) at dilution 1/35. (Original magnification: ×200)