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Rabbit Polyclonal Antibody to HIRA
货号: P04612
别名: TUP1; DGCR1; TUPLE1
应用: IHC
反应种属: Human, Mouse
抗体类型: Primary antibody
Swissprot: P54198
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Description

This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.

Specification

Aliases TUP1; DGCR1; TUPLE1
Swissprot P54198
Host/Isotype Rabbit IgG
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human, Mouse
Immunogen Synthetic peptide of human HIRA
Formulation Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.

Application

IHC 1/20-1/100
ELISA 1/2000-1/5000
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