Rabbit Polyclonal Antibody to SRGAP1
货号：
P05359
别名：
ARHGAP13
应用：
WB,IHC
反应种属：
Human, Mouse
抗体类型：
Primary antibody
Swissprot：
Q7Z6B7
规格：
目录价
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Description |
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SRGAP1 contains an FCH (Fes/CIP4 homology) domain, a Rho-GAP domain and an SH3 domain. In the presence of Slit, SRGAP1 (via its SH3 domain) binds to the CC3 motif in robo (a protein responsible for mediating the repulsive effect of Slit) with higher affinity and inhibits Cdc42 activity in a robo/SRGAP-dependent manner. More specifically, SRGAP1 increases the intrinsic GTPase activity of Cdc42, thereby converting it to its inactive, GDP-bound form. Inactivation of Cdc42 ultimately leads to a decrease in actin polymerization. |
Specification |
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|---|---|
| Aliases | ARHGAP13 |
| Swissprot | Q7Z6B7 |
| WB Predicted band size | 124 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human SRGAP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
Application |
|
|---|---|
| WB | 1/500-1/2000 |
| IHC | 1/25-1/100 |
| ELISA | 1/2000-1/5000 |
Product Image
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Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Hepg2 cells, TM4 cells, 293T cells, NIH/3T3 cells, Primary antibody: P05359(SRGAP1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
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The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P05359(SRGAP1 Antibody) at dilution 1/25. (Original magnification: ×200)
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The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P05359(SRGAP1 Antibody) at dilution 1/25. (Original magnification: ×200)
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