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Mouse Monoclonal Antibody to CDK4
货号: 20445
别名: CMM3; PSK-J3
应用: WB,IHC,FCM
反应种属: Human,Mouse
抗体类型: Primary antibody
Swissprot: P11802
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Description

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.

References

1.FEBS Lett. 2012 Feb 17;586(4):442-7.
2.J Transl Med. 2011 Apr 11;9:38.

Specification

Aliases CMM3; PSK-J3
Entrez GeneID 1019
Swissprot P11802
clone 4C5H9
WB Predicted band size 33.7kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human,Mouse
Immunogen Purified recombinant fragment of human CDK4 expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

WB 1/500 - 1/2000
IHC 1/200 - 1/1000
FCM 1/200 - 1/400
ELISA 1/10000
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