Rabbit Polyclonal Antibody to ALOX5
货号:
P06977
别名:
5-LO, 5LPG, LOG5, 5-LOX
应用:
IHC
反应种属:
Human, Mouse, Rat
抗体类型:
Primary antibody
Swissprot:
P09917
规格:
目录价
在线咨询
Description |
---|
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Specification |
|
---|---|
Aliases | 5-LO, 5LPG, LOG5, 5-LOX |
Swissprot | P09917 |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human, Mouse, Rat |
Immunogen | Fusion protein of human ALOX5 |
Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
Application |
|
---|---|
IHC | 1/25-1/100 |
ELISA | 1/500-1/2000 |
Product Image
-
The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P06977(ALOX5 Antibody) at dilution 1/25. (Original magnification: ×200)
-
The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P06977(ALOX5 Antibody) at dilution 1/25. (Original magnification: ×200)