Mouse Monoclonal Antibody to WDR5
货号：
30073
别名：
SWD3; BIG-3; WDR5
应用：
WB
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
P61964
规格：
目录价
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Description |
|---|
WD-repeat protein 5 (WDR5, also designated BMP-2-induced gene 3 kb or BIG-3) belongs to the family of WD-40 repeat proteins, and is essential for vertebrate development, Hox gene activation and global H3K4 trimethylation. WDR5 is a conserved subunit of Trithorax (TRX) histone methyltransferase complexes that selectively binds to dimethylated Lys4 (K4me2) in Histone H3 to promote K4 trimethylation by TRX. It is expressed in osteoblasts, chondrocytes, osteocytes and marrow stromal cells. The WDR5 protein contains 7 WD-repeats, which may play a role in its function of accelerating osteoblast differentiation. |
References |
|---|
| 1. Mol Syst Biol. 2007;3:89. 2. J Biol Chem. 2008 Nov 21;283(47):32162-75. |
Specification |
|
|---|---|
| Aliases | SWD3; BIG-3; WDR5 |
| Entrez GeneID | 11091 |
| Swissprot | P61964 |
| clone | 7B11 |
| WB Predicted band size | 36.6kDa |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human WDR5 expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
Application |
|
|---|---|
| WB | 1/500 - 1/2000 |
| ELISA | 1/10000 |
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