Rabbit Polyclonal Antibody to DOK3
货号：
P07260
别名：
DOKL
应用：
WB,IHC
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
Q7L591
规格：
目录价
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Description |
|---|
DOK3 gene maps to chromosome 5q35.3. Dok3 was tyrosine phosphorylated by Src family members Lck, Fyn, and Lyn. Immunoprecipitation studies showed that Dok3 bound inhibitors SHIP and Csk but did not bind RasGAP. Dok3 binding to SHIP occurred via the SH2 domain. Dok3 also bound Csk via the Csk SH2 domain with possible involvement of the Csk SH3 domain as well.DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function |
Specification |
|
|---|---|
| Aliases | DOKL |
| Swissprot | Q7L591 |
| WB Predicted band size | 53 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human DOK3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
Application |
|
|---|---|
| WB | 1/200-1/1000 |
| IHC | 1/25-1/100 |
| ELISA | 1/1000-1/2000 |
Product Image
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Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human notum skin cancer tissue, Primary antibody: P07260(DOK3 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds
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The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P07260(DOK3 Antibody) at dilution 1/25. (Original magnification: ×200)
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