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Mouse Monoclonal Antibody to KLHL13
货号: 30067
别名: BKLHD2; FLJ10262; MGC74791; KLHL13
应用: WB,IHC,IF,FCM
反应种属: Human
抗体类型: Primary antibody
Swissprot: Q9P2N7
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Description

KLHL13 (kelch-like 13), also known as BKLHD2 (BTB and kelch domain-containing protein 2), is a 604 amino acid protein that contains six Kelch repeats and one BTB/POZ domain. Expressed predominantly in brain, KLHL13 is believed to play a role in protein ubiquitination and may function as a substrate- specific adapter of an E3 ubiquitin-protein ligase complex. E3 ligases accept a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and immediately transfer that residue to a protein that is targeted for degradation. Specifically, KLHL13 interacts with KLHL9 and CUL-3, a member of the cullin family of mediators that participate in the selective targeting of proteins for ubiquitin-mediated proteolysis. Via its BTB and C-terminal Kelch (BACK) motif, KLHL13 is thought to play a role in spatially orientating substrates in the CUL-3 ligase.

References

1. DNA Res. 2000 Feb 28;7(1):65-73.
2. Genome Res. 2004 Sep;14(9):1711-8.
3. Cell. 2009 Jul 23;138(2):389-403.

Specification

Aliases BKLHD2; FLJ10262; MGC74791; KLHL13
Entrez GeneID 90293
Swissprot Q9P2N7
clone 8D1
WB Predicted band size 74kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human KLHL13 expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.

Application

WB 1/500 - 1/2000
IHC 1/200 - 1/1000
IF 1/200 - 1/1000
FCM 1/200 - 1/400
ELISA 1/10000
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