Mouse Monoclonal Antibody to SMAD6
货号：
30097
别名：
MADH6; MADH7; HsT17432; SMAD6
应用：
WB
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
O43541
规格：
目录价
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Description |
|---|
Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions.Tissue specificity: Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue. |
References |
|---|
| 1. J Biol Chem. 2006 Feb 10;281(6):3569-76. 2. Nat Immunol. 2006 Oct;7(10):1057-65. 3. J Med Genet. 2009 May;46(5):331-7. |
Specification |
|
|---|---|
| Aliases | MADH6; MADH7; HsT17432; SMAD6 |
| Entrez GeneID | 4091 |
| Swissprot | O43541 |
| clone | 5H3 |
| WB Predicted band size | 53kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human SMAD6 expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500 - 1/2000 |
| ELISA | 1/10000 |
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