Mouse Monoclonal Antibody to STAT3
货号：
30122
别名：
APRF; HIES; FLJ20882; MGC16063; STAT3
应用：
WB,IHC,IF
反应种属：
Human,Mouse,Monkey
抗体类型：
Primary antibody
Swissprot：
P40763
规格：
目录价
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Description |
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The Stat3 transcription factor is an important signaling molecule for many cytokines and growth-factor receptors and is required for murine fetal development . Stat3 is constitutively activated in a number of human tumors and possesses oncogenic potential and anti-apoptotic activities. Stat3 is activated by phosphorylation at Tyr705, which induces dimerization, nuclear translocation and DNA binding. Transcriptional activation seems to be regulated by phosphorylation at Ser727 through the MAPK or mTOR pathways. Stat3 isoform expression appears to reflect biological function as the relative expression levels of Stat3a (86 kDa) and Stat3 |
References |
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| 1. J Mol Graph Model. 2009 Nov;28(4):347-56. 2. Bone. 2010 Feb;46(2):524-33. |
Specification |
|
|---|---|
| Aliases | APRF; HIES; FLJ20882; MGC16063; STAT3 |
| Entrez GeneID | 6774 |
| Swissprot | P40763 |
| clone | 3B5 |
| WB Predicted band size | 88kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Monkey |
| Immunogen | Purified recombinant fragment of human STAT3 expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/1000 |
| IHC | 1/200 - 1/1000 |
| IF | 1/200 - 1/1000 |
| ELISA | 1/10000 |
Product Image
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Western blot analysis using STAT3 mouse mAb against Hela (1),NIH/3T3 (2), Jurkat (3), PC-12 (4) and COS7 (5) cell lysate.
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Western blot analysis using STAT3 mouse mAb against NRK(1),C2C12(2),C6(3),81505(4),KO-SF(5),RSC-96(6),NIH/3T3(7),Hela(8),Jurkat(9) cell lysate.
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Immunofluorescence analysis of Hela cells using STAT3 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
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Immunohistochemical analysis of paraffin-embedded human mammary cancer tissues (left) and lung cancer tissues (right) using STAT3 mouse mAb with DAB staining.
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