Rabbit Polyclonal Antibody to NR3C1
货号:
P08372
别名:
GR; GCR; GRL; GCCR; GCRST
应用:
WB,IHC
反应种属:
Human, Mouse, Rat
抗体类型:
Primary antibody
Swissprot:
P04150
规格:
目录价
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Description |
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This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities. |
Specification |
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Aliases | GR; GCR; GRL; GCCR; GCRST |
Swissprot | P04150 |
WB Predicted band size | 86 kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human, Mouse, Rat |
Immunogen | Fusion protein of human NR3C1 |
Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
Application |
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WB | 1/500-1/2000 |
IHC | 1/50-1/200 |
ELISA | 1/5000-1/10000 |
Product Image
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Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-8: K562, 231, Hela, HepG2 cell, Mouse liver tissue, A172 cell, Jurkat cell, Mouse smooth muscle cell lysates, Primary antibody: P08372(NR3C1 Antibody) at dilution 1/700, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 2 minutes
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The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08372(NR3C1 Antibody) at dilution 1/30. (Original magnification: ×200)
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The image is immunohistochemistry of paraffin-embedded Human brain tissue using P08372(NR3C1 Antibody) at dilution 1/30. (Original magnification: ×200)