Mouse Monoclonal Antibody to PRKDC
货号：
30170
别名：
HYRC; p350; DNAPK; DNPK1; HYRC1; XRCC7; DNA-PKcs; PRKDC
应用：
IHC,IF
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
P78527
规格：
目录价
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Description |
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The PRKDC gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK). The second component is the autoimmune antigen Ku (MIM 152690), which is encoded by the G22P1 gene on chromosome 22q. On its own, the catalytic subunit of DNA-PK is inactive and relies on the G22P1 component to direct it to the DNA and trigger its kinase activity; PRKDC must be bound to DNA to express its catalytic properties. |
References |
|---|
| 1. J Biol Chem. 2008 Dec 26;283(52):36311-20. 2. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12791-6. |
Specification |
|
|---|---|
| Aliases | HYRC; p350; DNAPK; DNPK1; HYRC1; XRCC7; DNA-PKcs; PRKDC |
| Entrez GeneID | 5591 |
| Swissprot | P78527 |
| clone | 3H6 |
| WB Predicted band size | 46.9kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human PRKDC expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
Application |
|
|---|---|
| IHC | 1/200 - 1/1000 |
| IF | 1/200 - 1/1000 |
| ELISA | 1/10000 |
Product Image
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Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);
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Immunofluorescence analysis of Hela cells using PRKDC mouse mAb (green). Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
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Immunohistochemical analysis of paraffin-embedded human breast cancer (left) and colon cancer (right) using PRKDC mouse mAb with DAB staining.
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Immunohistochemical analysis of paraffin-embedded human lung cancer (left) and brain tissues (right) using PRKDC mouse mAb with DAB staining.
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