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Mouse Monoclonal Antibody to CCND3
货号: 30186
别名: CCND3
应用: WB
反应种属: Human,Mouse
抗体类型: Primary antibody
Swissprot: P30281
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Description

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene.

References

1. Blood. 2008 Jun 15;111(12):5683-90.
2. Pathol Res Pract. 2008;204(8):589-97.

Specification

Aliases CCND3
Entrez GeneID 896
Swissprot P30281
clone 6H4
WB Predicted band size 32kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human,Mouse
Immunogen Purified recombinant fragment of human CCND3 expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

ELISA 1/10000
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