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Mouse Monoclonal Antibody to CRK
货号: 30256
别名: CRKII
应用: IHC,IF,FCM
反应种属: Human
抗体类型: Primary antibody
Swissprot: P46108
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Description

This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.

References

1. Seikagaku. 2009 May;81(5):361-76. 
2. Mol Cancer Res. 2009 Sep;7(9):1582-92.

Specification

Aliases CRKII
Entrez GeneID 1398
Swissprot P46108
clone 3G11C1
WB Predicted band size 42kDa
Host/Isotype Mouse IgG2b
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human CRK expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.

Application

IHC 1/200 - 1/1000
IF 1/200 - 1/1000
FCM 1/200 - 1/400
ELISA 1/10000
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