Rabbit Polyclonal Antibody to CDK2AP1
货号:
P09470
别名:
DOC1; ST19; DORC1; doc-1; p12DOC-1
应用:
IHC
反应种属:
Human, Mouse
抗体类型:
Primary antibody
Swissprot:
O14519
规格:
目录价
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Description |
|---|
The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
Specification |
|
|---|---|
| Aliases | DOC1; ST19; DORC1; doc-1; p12DOC-1 |
| Swissprot | O14519 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
Application |
|
|---|---|
| IHC | 1/25-1/100 |
| ELISA | 1/5000-1/10000 |


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