Rabbit Polyclonal Antibody to NR1I3
货号:
P09542
别名:
CAR; CAR1; MB67
应用:
IHC
反应种属:
Human
抗体类型:
Primary antibody
Swissprot:
Q14994
规格:
目录价
在线咨询
Description |
---|
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. |
Specification |
|
---|---|
Aliases | CAR; CAR1; MB67 |
Swissprot | Q14994 |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen | Fusion protein of human NR1I3 |
Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
Application |
|
---|---|
IHC | 1/25-1/100 |
ELISA | 1/5000-1/10000 |
Product Image
-
The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P09542(NR1I3 Antibody) at dilution 1/20. (Original magnification: ×200)
-
The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P09542(NR1I3 Antibody) at dilution 1/20. (Original magnification: ×200)