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Mouse Monoclonal Antibody to TNNI2
货号: 30278
别名: DA2B; FSSV; fsTnI; AMCD2B
应用: IHC,FCM
反应种属: Human
抗体类型: Primary antibody
Swissprot: P48788
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Description

This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene.

References

1. Am J Hum Genet. 2009 Nov;85(5):628-42.
2. Cell Motil Cytoskeleton. 2008 Aug;65(8):652-61.

Specification

Aliases DA2B; FSSV; fsTnI; AMCD2B
Entrez GeneID 7136
Swissprot P48788
clone 2F12A8
WB Predicted band size 21kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human TNNI2 expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.

Application

IHC 1/200 - 1/1000
FCM 1/200 - 1/400
ELISA 1/10000
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