Rabbit Polyclonal Antibody to RRP8
货号：
P10170
别名：
NML; KIAA0409
应用：
WB,IHC
反应种属：
Human, Mouse, Rat
抗体类型：
Primary antibody
Swissprot：
O43159
规格：
目录价
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Description |
|---|
Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown. |
Specification |
|
|---|---|
| Aliases | NML; KIAA0409 |
| Swissprot | O43159 |
| WB Predicted band size | 51 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human RRP8 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
Application |
|
|---|---|
| WB | 1/500-1/2000 |
| IHC | 1/50-1/300 |
| ELISA | 1/5000-1/10000 |
Product Image
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Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human cerebella tissue, K562 cell lysates, Primary antibody: P10170(RRP8 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 30 seconds
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The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P10170(RRP8 Antibody) at dilution 1/80. (Original magnification: ×200)
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The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P10170(RRP8 Antibody) at dilution 1/80. (Original magnification: ×200)
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