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Mouse Monoclonal Antibody to RAF1
货号: 30325
别名: NS5; CRAF; Raf-1; c-Raf
应用: WB,IHC,FCM
反应种属: Human
抗体类型: Primary antibody
Swissprot: P04049
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Description

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.

References

1. Am J Hum Genet. 2009 Nov;85(5):628-42.
2. Mol Cancer Res. 2009 Oct;7(10):1635-44.

Specification

Aliases NS5; CRAF; Raf-1; c-Raf
Entrez GeneID 5894
Swissprot P04049
clone 4G4
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human RAF1 expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

WB 1/500 - 1/2000
IHC 1/200 - 1/1000
FCM 1/200 - 1/400
ELISA 1/10000
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