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Rabbit Polyclonal Antibody to IFT57
货号: P10157
别名: HIPPI; MHS4R2; ESRRBL1
应用: IHC
反应种属: Human, Mouse
抗体类型: Primary antibody
Swissprot: Q9NWB7
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Description

Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.

Specification

Aliases HIPPI; MHS4R2; ESRRBL1
Swissprot Q9NWB7
Host/Isotype Rabbit IgG
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human, Mouse
Immunogen Fusion protein of human IFT57
Formulation Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.

Application

IHC 1/50-1/300
ELISA 1/5000-1/10000
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