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Mouse Monoclonal Antibody to FAS
货号: 30326
别名: APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6
应用: WB,IF,FCM
反应种属: Human
抗体类型: Primary antibody
Swissprot: P25445
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Description

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.

References

Am J Hum Genet. 2009 Nov;85(5):628-42
Int J Surg Pathol. 2010 Dec;18(6):493-8

Specification

Aliases APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6
Entrez GeneID 355
Swissprot P25445
clone 4F8H6
WB Predicted band size 37.7kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human FAS expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

WB 1/500 - 1/2000
IF 1/200 - 1/1000
FCM 1/200 - 1/400
ELISA 1/10000
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