Rabbit Polyclonal Antibody to CCDC134
货号：
P10316
别名：
应用：
WB,IHC
反应种属：
Human, Mouse, Rat
抗体类型：
Primary antibody
Swissprot：
Q9H6E4
规格：
目录价
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Description |
|---|
In extracellular secreted form, promotes proliferation and activation of CD8+ T cells, suggesting a cytokine-like function (PubMed:25125657). Enhances cytotoxic anti-tumor activity of CD8+ T cells (PubMed:25125657). May inhibit ERK and JNK signaling activity (PubMed:18087676, PubMed:23070808). May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling (PubMed:23070808). In the nucleus, enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and thus promotes PCAF-mediated H3K14 and H4K8 HAT activity. May inhibit TADA2A-mediated TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote TADA2A-mediated XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage. |
Specification |
|
|---|---|
| Swissprot | Q9H6E4 |
| WB Predicted band size | 27 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human CCDC134 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
Application |
|
|---|---|
| WB | 1/1000-1/5000 |
| IHC | 1/50-1/200 |
| ELISA | 1/5000-1/10000 |
Product Image
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Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human fetal liver tissue, 293T cell lysates, Primary antibody: P10316(CCDC134 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 20 seconds
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The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P10316(CCDC134 Antibody) at dilution 1/50. (Original magnification: ×200)
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