Rabbit Polyclonal Antibody to GSDMA
货号：
P10525
别名：
GSDM; FKSG9; GSDM1
应用：
WB,IHC
反应种属：
Human, Mouse
抗体类型：
Primary antibody
Swissprot：
Q96QA5
规格：
目录价
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Description |
|---|
May promote pyroptosis (Probable). Upon cleavage in vitro of genetically engineered GSDMA, the released N-terminal moiety binds to some types of lipids, such as possibly phosphatidylinositol (4,5)-bisphosphate. Homooligomerizes within the membrane and forms pores of 10 -15 nanometers (nm) of inner diameter, triggering cell death. Also binds to bacterial and mitochondrial lipids, including cardiolipin, and exhibits bactericidal activity (PubMed:27281216). The physiological relevance of these observations is unknown (Probable). |
Specification |
|
|---|---|
| Aliases | GSDM; FKSG9; GSDM1 |
| Swissprot | Q96QA5 |
| WB Predicted band size | 49 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human GSDMA |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
Application |
|
|---|---|
| WB | 1/500-1/2000 |
| IHC | 1/150-1/300 |
| ELISA | 1/5000-1/10000 |
Product Image
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Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: 293T, Hela and LO2 cell lysates, Primary antibody: P10525(GSDMA Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute
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The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P10525(GSDMA Antibody) at dilution 1/150. (Original magnification: ×200)
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