Rabbit Polyclonal Antibody to CLDN8
货号:
P10901
别名:
应用:
IHC
反应种属:
Human
抗体类型:
Primary antibody
Swissprot:
P56748
规格:
目录价
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Description |
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This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma. |
Specification |
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Swissprot | P56748 |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen | Synthetic peptide of human CLDN8 |
Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
Application |
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IHC | 1/100-1/300 |
ELISA | 1/2000-1/10000 |
Product Image
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The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P10901(CLDN8 Antibody) at dilution 1/50. (Original magnification: ×200)
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The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P10901(CLDN8 Antibody) at dilution 1/50. (Original magnification: ×200)