Rabbit Polyclonal Antibody to SMURF2
货号：
P11210
别名：
应用：
IHC
反应种属：
Human, Mouse
抗体类型：
Primary antibody
Swissprot：
Q9HAU4
规格：
目录价
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Description |
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E3 ubiquitin-protein ligase SMURF2 is an enzyme that in humans is encoded by the SMURF2 gene. E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. |
Specification |
|
|---|---|
| Swissprot | Q9HAU4 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human SMURF2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
Application |
|
|---|---|
| IHC | 1/25-1/100 |
| ELISA | 1/1000-1/2000 |
Product Image
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The image is immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using P11210(SMURF2 Antibody) at dilution 1/15. (Original magnification: ×200)
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The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P11210(SMURF2 Antibody) at dilution 1/15. (Original magnification: ×200)
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