Rabbit Polyclonal Antibody to ATM
货号:
P12966
别名:
AT1; ATA; ATC; ATD; ATE; ATDC; TEL1; TELO1
应用:
IHC
反应种属:
Human
抗体类型:
Primary antibody
Swissprot:
Q13315
规格:
目录价
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Description |
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The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. |
Specification |
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Aliases | AT1; ATA; ATC; ATD; ATE; ATDC; TEL1; TELO1 |
Swissprot | Q13315 |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen | Synthetic peptide of human ATM |
Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
Application |
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IHC | 1/40-1/200 |
ELISA | 1/5000-1/10000 |
Product Image
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The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P12966(ATM Antibody) at dilution 1/65. (Original magnification: ×200)
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The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P12966(ATM Antibody) at dilution 1/65. (Original magnification: ×200)