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Mouse Monoclonal Antibody to MCAM
货号: 30560
别名: CD146; MUC18
应用: WB,IHC
反应种属: Human
抗体类型: Primary antibody
Swissprot: P43121
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Description

The protein encoded by this gene plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during
embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration

References

1. Cancer Lett. 2013 Apr 28;330(2):150-62.
2. J Biol Chem. 2013 Jan 25;288(4):2571-9.

Specification

Aliases CD146; MUC18
Entrez GeneID 4162
Swissprot P43121
clone 6C3F1
WB Predicted band size 71.6kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human MCAM (AA: 84-189) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

WB 1/500 - 1/2000
IHC 1/200 - 1/1000
ELISA 1/10000
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